Research Article
Single Nucleotide Polymorphism of Genes Associated with Metabolic Fatty Liver Disease
Table 4
Subgroup analysis among different severity of hepatotoxicity with different genetic models.
| Genes | tagSNPs | Model | Grade 4 and 3 (n = 65) | value | Grade 2 and 1 (n = 217) | value | OR (95% CI) | OR (95% CI) |
| PNPLA3 | rs738409 (G > C) | | | | | | GG | Dom | 1.198 (0.482–2.479) | 0.683 | 1.121 (0.685–1.633) | 0.507 | GC | Rec | 1.052 (0.581–1.876) | 0.749 | 1.614 (1.156–2.506) | 0.009 | CC | Add | 1.079 (0.754–1.732) | 0.738 | 1.279 (1.010–1.628) | 0.038 | MBOAT7 | rs64173 (C > T) | | | | | | CC | Dom | 0.796( 0.373–1.919) | 0.683 | 0.787 (0.463–1.349) | 0.298 | CT | Rec | – | – | 2.013 (0.115–5.97) | 0.654 | TT | Add | 0.861 (0.392–1.896) | 0.687 | 0.830 (0.519–1.316) | 0.438 | STAT3 | rs744166 (G > A) | | | | | | GG | Dom | 1.417 (0.812–2.389) | 0.221 | 1.219 (0.891–1.672) | 0.229 | GA | Rec | 0.827 (0.355–1.863) | 0.675 | 1.464 (0.862–2.483) | 0.150 | AA | Add | 1.152 (0.891–1.810) | 0.488 | 1.217 (0.961–1.533) | 0.135 | TM6SF2 | rs58542926 (C > T) | | | | | | CC | Dom | 1.011 (0.524–1.838) | 0.921 | 0.885 (0.629–1.252) | 0.518 | CT | Rec | 0.787 (0.376–1.632) | 0.528 | 1.062 (0.729–1.537) | 0.886 | TT | Add | 0.954 (0.662–1.399) | 0.792 | 0.973 (0.772–1.219) | 0.769 | GATAD2A | rs4808199 (G > A) | | | | | | AA | Dom | 0.618 (0.345–1.096) | 0.095 | 1.215 (0.885–1.669) | 0.266 | AG | Rec | 1.122 (0.519–2.481) | 0.789 | 1.090 (0.712–1.683) | 0.693 | GG | Add | 0.816 (0.540–1.226) | 0.316 | 1.125 (0.896–1.387) | 0.392 |
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