Single Nucleotide Polymorphism of Genes Associated with Metabolic Fatty Liver Disease

Table 4

Subgroup analysis among different severity of hepatotoxicity with different genetic models.

Genes	tagSNPs	Model	Grade 4 and 3 (n = 65)	value	Grade 2 and 1 (n = 217)	value
			OR (95% CI)		OR (95% CI)
PNPLA3	rs738409 (G > C)
	GG	Dom	1.198 (0.482–2.479)	0.683	1.121 (0.685–1.633)	0.507
	GC	Rec	1.052 (0.581–1.876)	0.749	1.614 (1.156–2.506)	0.009
	CC	Add	1.079 (0.754–1.732)	0.738	1.279 (1.010–1.628)	0.038
MBOAT7	rs64173 (C > T)
	CC	Dom	0.796( 0.373–1.919)	0.683	0.787 (0.463–1.349)	0.298
	CT	Rec	–	–	2.013 (0.115–5.97)	0.654
	TT	Add	0.861 (0.392–1.896)	0.687	0.830 (0.519–1.316)	0.438
STAT3	rs744166 (G > A)
	GG	Dom	1.417 (0.812–2.389)	0.221	1.219 (0.891–1.672)	0.229
	GA	Rec	0.827 (0.355–1.863)	0.675	1.464 (0.862–2.483)	0.150
	AA	Add	1.152 (0.891–1.810)	0.488	1.217 (0.961–1.533)	0.135
TM6SF2	rs58542926 (C > T)
	CC	Dom	1.011 (0.524–1.838)	0.921	0.885 (0.629–1.252)	0.518
	CT	Rec	0.787 (0.376–1.632)	0.528	1.062 (0.729–1.537)	0.886
	TT	Add	0.954 (0.662–1.399)	0.792	0.973 (0.772–1.219)	0.769
GATAD2A	rs4808199 (G > A)
	AA	Dom	0.618 (0.345–1.096)	0.095	1.215 (0.885–1.669)	0.266
	AG	Rec	1.122 (0.519–2.481)	0.789	1.090 (0.712–1.683)	0.693
	GG	Add	0.816 (0.540–1.226)	0.316	1.125 (0.896–1.387)	0.392