Journal of Oncology / 2022 / Article / Tab 2 / Review Article
Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment Table 2 Examples of different endogenous stimuli-based drug delivery options and their different carrier systems along with their application.
Stimulus Carrier Associated cargo Application Ref Hypoxia Mesoporous silica nanoparticles Oligonucleotide (CpG) and chlorin e6 Cancer therapy to boost the immune system [156 ] Upconversion nanoparticles Tirapazamine and indocyanine green Treatment of tumor by implementing photodynamic therapy (PDT) and chemotherapy [157 ] Polymeric micelles Doxorubicin Radiotherapy and chemotherapy for treating cancer [158 ] Albumin nanoparticles Oxaliplatin prodrug and Ce6 PDT and chemotherapy in cancer [159 ] Redox Polymersomes Doxorubicin Chemotherapy for lung carcinoma [160 ] Nanoparticles Paclitaxel Drug release by triggering GSH and targeted therapy to activate tumor [161 ] Polyphosphazene nanoparticles Doxorubicin Redox-stimulated chemotherapy and photo-thermal therapy [162 ] Nanoparticles Catalase and photosensitizer of methylene blue Hypoxic cancer cells are treated using H2O2-responsive drug release and a light triggering mechanism [163 ] pH Polymeric micelles Epirubicin Intracellular release of drug [164 ] CaP nanocarriers Mn2+ Detection of ultrasmall liver metastasis and imaging of solid tumors in addition to neutron capture therapy [165 ]