FCGR3A Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lower-Grade Glioma

Table 1

Correlation analysis between FCGR3A and related genes and markers of immune cells in LGG using TIMER and GEPIA databases.

Description	Gene markers	LGG (TIMER)				LGG (GEPIA)
		None		Purity
		cor		cor		R
CD8^+T cell	CD8A	0.2719		0.2843		0.3
	CD8B	0.2471		0.2713		0.26
T cell (general)	CD3D	0.5282		0.5476		0.49
	CD3E	0.5893		0.6117		0.6
	CD2	0.5923		0.6058		0.61
B cell	CD19	0.4395		0.4341		0.55
	CD79A	0.3709		0.3921		0.38
Monocyte	CD86	0.7949		0.8023		0.8
	CSF1R	0.6704		0.6720		0.67
TAM	CCL2	0.5687		0.5589		0.58
	CD68	0.7838		0.7931		0.78
	PD-L1 (CD274)	0.4561		0.4616		0.54
	PD-L2 (PDCD1LG2)	0.7379		0.7469		0.74
	IL10	0.6571		0.6514		0.65
M1 macrophage	INOS (NOS2)	−0.1623		−0.1449		−0.15
	IRF5	0.7079		0.7169		0.7
	COX2 (PTGS2)	0.1645		0.1566		0.21
M2 macrophage	CD163	0.5708		0.5581		0.56
	VSIG4	0.7058		0.7030		0.71
	MS4A4A	0.6396		0.6444		0.65
Neutrophils	CD66b (CEACAM8)	0.0304	0.4902	0.0232	0.6131	0.03	0.5000
	CD11b (ITGAM)	0.7129		0.7152		0.71
	CCR7	0.4100		0.4265		0.42
Natural killer cell	KIR2DL1	0.0730	0.0977	0.0914		0.14
	KIR2DL3	0.2595		0.2808		0.26
	KIR2DL4	0.4566		0.4752		0.49
	KIR3DL1	0.0670	0.1284	0.0715	0.1182	0.15
	KIR3DL2	0.1890		0.2042		0.2
	KIR3DL3	0.0562	0.2023	0.0362	0.4287	0.057	0.1900
	KIR2DS4	0.2158		0.2379		0.22
Dendritic cell	HLA-DPB1	0.7614		0.7645		0.77
	HLA-DQB1	0.6223		0.6245		0.51
	HLA-DRA	0.8060		0.8044		0.81
	HLA-DPA1	0.7780		0.7813		0.78
	BDCA-1 (CD1C)	0.4226		0.4342		0.45
	BDCA-4 (NRP1)	0.3271		0.3277		0.32
	CD11c (ITGAX)	0.5944		0.6012		0.57
Th1	T-bet (TBX21)	0.3742		0.3753		0.41
	STAT4	−0.1408		−0.1228		−0.098
	STAT1	0.5176		0.5159		0.54
	IFN-γ (IFNG)	0.2490		0.2547		0.28
	TNF-α (TNF)	0.2990		0.2856		0.32
Th2	GATA3	0.4229		0.4314		0.4
	STAT6	0.4826		0.5005		0.5
	STAT5A	0.6670		0.6630		0.67
	IL13	−0.0299	0.4986	−0.0314	0.4923	0.0039	0.93
Tfh	BCL6	0.1152		0.0834	0.0681	0.1500
	IL21	0.1336		0.1174		0.21
Th17	STAT3	0.5832		0.5700		0.57
	IL17A	0.0141	0.7500	−0.0082	0.8571	0.0200	0.6500
Treg	FOXP3	−0.1947		−0.1748		−0.14
	CCR8	0.1704		0.1853		0.21
	STAT5B	−0.0002	0.9962	−0.0272	0.5532	0.038	0.38
	TGFβ (TGFB1)	0.6535		0.6578		0.66
T cell exhaustion	PD-1 (PDCD1)	0.5345		0.5401		0.54
	CTLA4	0.4502		0.4482		0.45
	LAG3	0.2541		0.2590		0.23
	TIM-3 (HAVCR2)	0.8174		0.8231		0.82
	GZMB	0.3520		0.3627		0.36

LGG: brain lower grade glioma; TAM: tumor-associated macrophage; Th: T helper cell; Tfh: follicular helper T cell; Treg: regulatory T cell; Cor: R-value of Spearman’s correlation; none: correlation without adjustment. Purity: correlation adjusted by purity.-value significant codes: 0 ≤ <0.001 ≤ <0.01 ≤ <0.05 ≤.