Identification and Validation of Three-Gene Signature in Lung Squamous Cell Carcinoma by Integrated Transcriptome and Methylation Analysis

<div>Inhibition of ABCC5, CLDH1, and CSTA reduced the carcinogenesis of NSCLC cells. (a) Representative images of EDU staining for Control, siABCC5, siCLDN1, and siCSTA groups. Magnification, ×200. (b) Comparison of colonies number among control, siABCC5, siCLDN1, and siCSTA groups. (c) Representative images of invasive ability comparison among Control, siABCC5, siCLDN1, and siCSTA groups. Magnification, ×100. Data are displayed as the mean ± standard deviation. 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NSCLC, non-small-cell lung cancer; EDU, 5-ethynyl-2′-deoxyuridine; ABCC5, ATP-binding cassette subfamily C member 5; CLDN1, Claudin 1; CSTA, Cystatin A.</div>

Journal of Oncology

fig6

Figure 6

Figure 6: Identification and Validation of Three-Gene Signature in Lung Squamous Cell Carcinoma by Integrated Transcriptome and Methylation Analysis 