Integrative Multiomics Evaluation of IIDH1 Metabolic Enzyme as a Candidate Oncogene That is Correlated with Poor Prognosis and Immune Infiltration in Prostate Adenocarcinoma

Figure 7

In silico and in vitro characterization of the inhibitory activity of oxalomalic acid against IDH1 in prostate cancer cells. (a) Oxalomalic acid treatment simulates the effect of IDH1 inhibition on prostate cancer cell lines. (b) CMap analysis was performed to explore the similarity between IDH1 and drug-induced genetic features in multiple cancer cell lines to assess the effect.

(a)

(b)