Pseudogene MSTO2P Interacts with miR-128-3p to Regulate Coptisine Sensitivity of Non-Small-Cell Lung Cancer (NSCLC) through TGF-β Signaling and VEGFC

Figure 1

Coptisine inhibited tumorigenesis of NSCLC cells. (a) Cell viabilities were examined by MTT in A549 and Calu-1 cells treated with or without coptisine. , coptisine group vs. mock group. (b and c) Cell apoptosis of A549 and Calu-1 cells were examined by TUNEL treated with or without coptisine. , , coptisine group vs. mock group. Scale bar = 5 μm. (d and e) Transwell assay showed invasion of A549 and Calu-1 cells treated with or without coptisine. , coptisine group vs. mock group. Scale bar = 5 μm. (f) MSTO2P levels were measured by RT-qPCR in A549 and Calu-1 cells treated with or without coptisine. , coptisine group vs. mock group.

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