Pseudogene MSTO2P Interacts with miR-128-3p to Regulate Coptisine Sensitivity of Non-Small-Cell Lung Cancer (NSCLC) through TGF-β Signaling and VEGFC

Figure 3

MSTO2P and miR-128-3p regulated TGF-β pathway (a) TGFBR1, Smad2, Smad5 and Smad9 were identified as targets of miR-128-3p by TargetScan. (b–e) RT-qPCR showed that TGFBR1, Smad2, Smad5 and Smad9 levels in A549 cells transfected with NC mimic, miR-128-3p mimic, NC inhibitor, miR-128-3p inhibitor. , miR-128-3p mimic group vs. NC mimic group, miR-128-3p inhibitor group vs. NC inhibitor group. (f–i) RT-qPCR showed that TGFBR1, Smad2, Smad5 and Smad9 levels in A549 cells transfected with si-NC or si-MSTO2P. , si-MSTO2P group vs. Si-NC group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)