Comprehensive Molecular Analyses of Notch Pathway-Related Genes to Predict Prognosis and Immunotherapy Response in Patients with Gastric Cancer

Figure 2

Construction of a prognostic signature in GC from TCGA. (a) Hazard ratios for three differentially expressed NPRGs that were implicated in overall survival plotted on a forest plot. (b) Three-fold cross-validation for tuning parameter selection in the LASSO model. (c) Profiles of differentially expressed NPRGs using the LASSO coefficient. The value determined using a three-fold cross-validation is indicated by the dashed line. (d) Principal component analysis based on NPRGs in GC. (e) In order to differentiate tumor samples from normal ones in the TCGA cohort, principal component analysis was performed based on a risk score. Patients who were considered to have a high risk were represented by the group that was colored green, while patients who were considered to have a low risk were represented by the group that was colored red.

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