Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma

<div>Effects of INPP4B overexpression on apoptosis levels in etoposide-resistant Y79 and RB355 cells. INPP4B overexpression (OE) increases the caspase-mediated apoptosis levels of etoposide-resistant (Etop) Y79 and RB355 cells compared to control cells (ctr) as revealed by DAPI cell counts (a) and caspase 3/7 assays (b). (c) Exemplary immunocytochemical stains of INPP4B overexpressing etoposide resistant Y79 and RB355 and control cells with an active, cleaved caspase-3 antibody (red fluorescence) and DAPI (blue fluorescence) counterstaining. White arrowheads indicate capase-3 positive cells. Magnification: 200x. All experiments were performed at least in triplicate and results were depicted with a standard error of the mean (SEM). 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Journal of Oncology

Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma

Figure 4