Index Before therapy After treatment NMHR (n = 93) MHR (n = 54) NMHR (n = 93) MHR (n = 54) Form Rule 3 (3.2) 1 (1.9) 0.622 5 (5.4) 3 (5.8) 1.000 Irregular 90 (96.8) 53 (98.1) 88 (94.6) 49 (94.2) Direction Level 83 (89.2) 51 (94.4) 0.442 85 (91.4) 46 (92.0) 1.000 Vertical bit 10 (10.8) 3 (5.6) 8 (8.6) 4 (8.0) Strong echo halo None 59 (63.4) 18 (33.3) <0.001 66 (71.0) 52 (96.3) <0.001 Have 34 (36.6) 36 (66.7) 27 (29.0) 2 (3.7) Calcification None 43 (46.2) 23 (42.6) 0.668 22 (23.7) 16 (32.0) 0.281 Have 50 (53.8) 31 (57.4) 71 (76.3) 34 (68.0) Boundary Clear 53 (57.0) 22 (40.7) 0.057 22 (23.7) 7 (13.0) 0.116 Not clear 40 (43.0) 32 (59.3) 71 (76.3) 47 (87.0) Echo Very low 16 (17.2) 5 (9.4) 0.412 0.662 Low 74 (79.6) 44 (83.0) 69 (75.0) 35 (70.0) Mix 2 (2.2) 3 (5.7) 3 (3.3) 1 (2.0) Wait for an echo 1 (1.1) 1 (1.9) 20 (21.7) 14 (28.0) Rear echo attenuation None 64 (68.8) 47 (87.0) 0.013 49 (52.7) 32 (59.3) 0.440 Have 29 (31.2) 7 (13.0) 44 (47.3) 22 (40.7) Adler Level 0 0 (0.0) 2 (3.7) <0.001 10 (10.8) 38 (70.4) <0.001 Level 1 13 (14.0) 29 (53.7) 27 (29.0) 14 (25.9) Level 2 46 (49.5) 22 (40.7) 38 (40.9) 2 (3.7) Level 3 34 (36.6) 1 (1.9) 18 (19.4) 0 (0.0) Diameter 3.60 (2.40,5.05) 3.00 (2.08,4.80) 0.164 2.30 (1.40,4.00) 1.00 (0.70,1.80) <0.001 RI 0.74 (0.68,0.80) 0.62 (0.60,0.68) <0.001 0.68 (0.61,0.76) 0.00 (0.00,0.51) <0.001 CEA 2.71 (1.68,5.71) 2.34 (1.41,5.18) 0.436 2.60 (1.60,3.81) 1.85 (1.28,3.07) 0.003 CA125 16.23 (10.74,25.22) 14.11 (10.29,24.74) 0.674 14.41 (10.67,19.52) 13.97 (10.19,17.27) 0.210 CA153 18.49 (12.22,28.50) 12.70 (7.95,21.83) 0.003 20.47 (15.73,28.55) 15.65 (12.48,23.61) 0.006 CA50 5.40 (2.61,11.00) 4.95 (2.70,9.65) 0.629 7.35 (4.30,11.25) 6.80 (3.90,11.20) 0.591