METTL14 Regulates PLAGL2/β-Catenin Signaling Axis to Promote the Development of Nonsmall Cell Lung Cancer

Figure 4

METTL14 regulated PLAGL2 signaling to affect NSCLC cell function. (a) METTL14, PLAGL2, and β-catenin mRNA expressions. (b) METTL14, PLAGL2, β-catenin (total), and β-catenin (nuclear) protein expressions. (c) Plate clone formation assay to measure cell proliferation. (d) Trypan blue staining to detect cell death (cell viability). (e) Cell migration was monitored by wound healing assay. (f) Cell invasion was determined by Transwell assay. Comparisons among multiple groups were conducted by one-way analysis of variance (ANOVA), followed by Tukey’s post hoc test. ^∗ < 0.05 vs. sh-NC, ^# < 0.05 vs. sh-METTL14 + oe-NC.

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