Deciphering the Molecular Mechanism of Yifei-Sanjie Pill in Cancer-Related Fatigue

Figure 2

YFSJ reversed cancer-induced mitochondrial damage in skeletal muscle and inflammation levels. (a) Pictures of 28 day mice before sample collection. (b) Representative HE staining slice images of lung, liver, and spleen from 28 day mice; lung and liver, scale bars = 200 μm; spleen, scale bars = 500 μm; MT means metastasis; gece means germinal center. (c) Representative TEM slices images of skeletal muscle; scale bars = 5 μm or 2 μm; MP means mitophagosome; Spr means sarcoplasmic reticulum; M means mitochondrion; Z means Z disk; H means H band. (d) and (e) IL-6 and TNF-α concentrations in mice serum; data were presented as mean ± SD; and compared with the control group; ^#, ^##, ^### compared with the CRF group; ^& and ^&& compared with the low group; ^ns@ and ^@@ compared with the 14 day group; n = 4.

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