OLFML2A Overexpression Predicts an Unfavorable Prognosis in Patients with AML

Table 3

Univariate and multivariate Cox regression analysis of factors associated with OS in TCGA-AML.

Characteristics	Total (N)	HR (95% CI) univariate analysis	value univariate analysis	HR (95% CI) multivariate analysis	value multivariate analysis
Gender	140
Female	63	Reference
Male	77	1.030 (0.674–1.572)	0.892
Race	138
Asian and Black or African American	11	Reference
White	127	1.200 (0.485–2.966)	0.693
Age	140
≤60	79	Reference
>60	61	3.333 (2.164–5.134)	<0.001	2.859 (1.819–4.494)	<0.001
WBC count (×10^9/L)	139
≤20	75	Reference
>20	64	1.161 (0.760–1.772)	0.490
BM blasts (%)	140
≤20	59	Reference
>20	81	1.165 (0.758–1.790)	0.486
PB blasts (%)	140
≤70	66	Reference
>70	74	1.230 (0.806–1.878)	0.338
Cytogenetic risk	138
Favorable	31	Reference
Intermediate	76	2.957 (1.498–5.836)	0.002	2.031 (1.003–4.113)	0.049
Poor	31	4.157 (1.944–8.893)	<0.001	2.506 (1.134–5.535)	0.023
FAB classifications	139
M0	14	Reference
M1&M2&M3&M4&M5&M6&M7	125	1.033 (0.517–2.062)	0.927
OLFML2A	140
Low	71	Reference
High	69	2.362 (1.534–3.639)	<0.001	2.198 (1.409–3.429)	<0.001