ADRB2 Regulates the Proliferation and Metastasis of Gastrointestinal Stromal Tumor Cells by Enhancing the ETV1-c-KIT Signaling

Figure 4

ADRB2 promotes the proliferation and metastasis of gastrointestinal stromal tumors in animal experiments. (a) Images of excised tumors from nude mice. (b) Tumor growth curves were used to evaluate the growth of xenograft tumors. (c) Representative images of gastric orthotopic tumors. (d) H&E staining of gastric orthotopic tumors. (e) Tumor volume of gastric orthotopic tumors. (f) Representative images of live metastasis form gastric orthotopic tumors. (g) H&E staining of liver metastasis. (h) Number of metastatic nodes. (i, j) In vivo image system was used to show the metastasis in intravenous injection model. (k) Ki67 expression was detected by IHC. Data are presented as the mean ± SD. ^∗∗ < 0.01; ^∗∗∗ < 0.001.

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