Microdissecting the Hypoxia Landscape in Colon Cancer Reveals Three Distinct Subtypes and Their Potential Mechanism to Facilitate the Development of Cancer

Figure 3

Identification of the hypoxia-related differentially expressed genes (HRDEGs) in TCGA-COAD cohort. (a) Volcano plot of hypoxia-specific genes between hypoxia-high and hypoxia-low clusters. (b) Volcano plot of differentially expressed genes (DEGs) between tumor and adjacent normal tissues. (c) Venn diagram of HRDEGs. Bubble plots for GO (d) and KEGG (e) functional annotation of the 600 HRDEGs. GO: gene ontology. KEGG: Kyoto encyclopedia of genes and genomes.

(a)

(b)

(c)

(d)

(e)