Microdissecting the Hypoxia Landscape in Colon Cancer Reveals Three Distinct Subtypes and Their Potential Mechanism to Facilitate the Development of Cancer

Figure 4

Development of the HRI signature. (a) Forest plot of twenty-two prognostic genes obtained by univariate Cox regression. Kaplan–Meier curves and the log-rank test value for TCGA-COAD (b) and GSE17538 (d) datasets. The AUCs of the time-dependent ROC curves for TCGA-COAD (c) and GSE17538 (e) datasets. Comparison of HIF1A mRNA expression between HRI high-risk and low-risk groups in TCGA-COAD (f) and GSE17538 (g). AUC: area under the curve. ROC: receiver operating characteristic.

(a)

(b)

(c)

(d)

(e)

(f)

(g)