Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc

Figure 4

Differentially expressed protein spots in 2-DE gels by comparisons of PC3 T₁₂₀ vs PC3 T₀ and RWPE-1 T₁₂₀ vs RWPE-1 T₀. (a) Representative 2-DE gel images (in the left panel) of prostate cancer PC3 cells without zinc exposure (PC3 T₀) and with exogenous zinc exposure for 120 min (PC3 T₁₂₀). (b) Representative 2-DE gel images (in the right panel) of prostate normal RWPE-1 cells without zinc exposure (RWPE-1 T₀) and with exogenous zinc exposure for 120 min (RWPE-1 T₁₂₀). Each protein extract (100 μg) was resolved based on isoelectric point (pI) and molecular weight (MW). The differentially expressed protein spots are shown with red circles denoting upregulation and green circles denoting downregulation.

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