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Journal of Obesity
Volume 2010, Article ID 136502, 11 pages
http://dx.doi.org/10.1155/2010/136502
Research Article

Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model

1Research Division, Chugai Pharmaceutical Co., LTD., Shizuoka 412-8513, Japan
2Institute of Medical Sciences, Tokai University, Kanagawa 259-1193, Japan
3Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo 113-8655, Japan
4Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan
5Department of Nephrology, Hypertension and Endocrinology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan
6Service de Nephrologie, Universite Catholique de Louvain, 1200 Brussels, Belgium

Received 11 June 2009; Revised 7 October 2009; Accepted 16 November 2009

Academic Editor: Terry Huang

Copyright © 2010 Shuichi Ohtomo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). Daily caloric intake was the same in both groups. Nevertheless, the HC/LF group gained less weight. Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress. Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN. Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels.