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Journal of Obesity
Volume 2010, Article ID 174652, 9 pages
Research Article

Racial Disparities between the Sex Steroid Milieu and the Metabolic Risk Profile

1Laboratory of Clinical and Applied Physiology, University of Miami, P.O. Box 248065, Coral Gables, FL 33124, USA
2Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 S. Euclid Avenue, Louis street, MO 63110, USA
3Diabetes Research Institute, Miller School of Medicine, University of Miami, 1450 NW 10th Avenue, Miami, FL 33136, USA
4Department of Medicine, School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada K7L 3N6
5Clemson University, Clemson, SC 29634, USA

Received 30 September 2009; Revised 1 February 2010; Accepted 23 April 2010

Academic Editor: Eliot Brinton

Copyright © 2010 Arlette Perry et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims and Method. The present study examined the relationship between the metabolic risk profile (MRP) and total testosterone (TT) and free testosterone using the free androgen index (FAI) and sex hormone binding globulin (SHBG) in 36 Caucasian American (CA) and 30 African-American (AA) women volunteering for a weight loss study. Results. After controlling for age, significant relationships were found between TT and diastolic blood pressure ( 𝑃 = . 0 0 4 and 𝑃 = . 0 1 5 in CA and AA women, resp.). Additionally, total cholesterol ( 𝑃 = . 0 0 3 ), low density lipoprotein cholesterol ( 𝑃 = . 0 0 4 ), apolipoprotein B ( 𝑃 = . 0 0 6 ), and the total cholesterol/high density lipoprotein cholesterol ( 𝑃 = . 0 2 7 ) were significantly related to TT in AA women only. In CA women, similar measures of glucose/insulin status related to FAI, were also related to SHBG. In both CA and AA women, SHBG was related to waist ( 𝑃 = . 0 3 1 and 𝑃 = . 0 2 2 resp.). Conclusion. Our findings showed racial disparities in the relationship between the sex steroid milieu and the MRP in overweight/obese CA and AA women.