Effect of VPAC1 Blockade on Adipose Tissue Formation and Composition in Mouse Models of Nutritionally Induced Obesity

Table 1

Effect of VPAC1 blockade on development of adipose tissue in C57Bl/6 mice kept on high-fat diet for 15 weeks.

	MAb 23A11	MAb 1C8
Body weight start (g)	16.7 ± 0.37	16.7 ± 0.47
Body weight end (g)	40.1 ± 1.2	39.8 ± 1.1
SC fat
Weight (mg)	1490 ± 68	1470 ± 51
Adipocyte size ($\mu$m^2)	4220 ± 220${}^{*}$	3560 ± 150
Adipocyte density (×10^−6/$\mu$m^2)	250 ± 14${}^{*}$	290 ± 14
GON fat
Weight (mg)	2530 ± 180	2460 ± 77
Adipocyte size ($\mu$m^2)	5250 ± 260	5880 ± 290
Adipocyte density (×10^−6/$\mu$m^2)	200 ± 9.8	180 ± 8.2

Data are means $\pm$ SEM of 12 experiments in each group. ${}^{*}$$P\mathrm{\hspace{0.17em}\hspace{0.17em}}<\mathrm{\hspace{0.17em}\hspace{0.17em}}.05$versus MAb 1C8.