Effect of VPAC1 Blockade on Adipose Tissue Formation and Composition in Mouse Models of Nutritionally Induced Obesity

Table 2

Effect of VPAC1 blockade on metabolic parameters in C57Bl/6 mice kept on high-fat diet for 15 weeks.

	MAb 23A11	MAb 1C8
Glucose (mg/dL)	171 ± 12	175 ± 11
Insulin (ng/mL)	4.0 ± 0.70	3.1 ± 0.41
Leptin (ng/mL)	30 ±3.8	29 ± 2.1
Total cholesterol (mg/dL)	185 ± 18	191 ± 12
HDL cholesterol (mg/dL)	149 ± 13	160 ± 7.0
LDL cholesterol (mg/dL)	29 ± 5.0	23 ± 5.0
Triglycrides (mg/dL)	38 ± 5.0	41 ± 4.0

Data are means ± SEM of 12 determinations in each group.