Effect of VPAC1 Blockade on Adipose Tissue Formation and Composition in Mouse Models of Nutritionally Induced Obesity

Table 3

Effect of VPAC1 blockade on glucose tolerance and insulin resistance in lean and obese mice.

	Lean ($n\mathrm{\hspace{0.17em}\hspace{0.17em}}=$ 10)		Obese ($n$$=$ 6)
	MAb 23A11	MAb 1C8	MAb 23A11	MAb 1C8
Body weight (g)	19 ± 0.36	20 ± 0.32	45 ± 1.4	44 ± 0.54
Glucose tolerance (AUC)	41,060 ± 2,260	44,125 ± 3,260	25,000 ± 5,000	30,800 ± 2,700
Insulin resistance (AUC)	9,580 ± 760	8,160 ± 650	14,800 ± 680	13,800 ± 900

For both MAbs, data are means ± SEM of $n$ experiments in each group. AUC: area under the curve of glucose levels versus time