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Journal of Obesity
Volume 2010, Article ID 602537, 5 pages
http://dx.doi.org/10.1155/2010/602537
Clinical Study

Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients

1Group of Obesity & Metabolic Syndrome, Endocrinology Service, Hospital das Clínicas, Faculty of Medicine, University of Sao Paulo, 05410-000 São Paulo, Brazil
2Department of Nutrition and Dietitian, Clínica Alfredo Halpern, 05410-000 São Paulo, Brazil

Received 24 June 2009; Revised 17 November 2009; Accepted 3 December 2009

Academic Editor: Renato Pasquali

Copyright © 2010 Alfredo Halpern et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. C. Seidell, “Obesity in Europe: scaling an epidemic,” International Journal of Obesity, vol. 19, supplement 3, pp. S1–S4, 1995. View at Google Scholar · View at Scopus
  2. F. X. Pi-Sunyer, “Medical hazards of obesity,” Annals of Internal Medicine, vol. 119, no. 7, part 2, pp. 655–660, 1993. View at Google Scholar · View at Scopus
  3. G. A. Bray, “Health hazards of obesity,” Endocrinology and Metabolism Clinics of North America, vol. 25, no. 4, pp. 907–919, 1996. View at Publisher · View at Google Scholar · View at Scopus
  4. P. R. Thomas, Ed., Weighing the Options: Criteria for Evaluating Weight-Management Programs, National Academy Press, Washington, DC, USA, 1996.
  5. S. Z. Yanovski, “Long-term pharmacotherapy in the management of obesity,” Journal of the American Medical Association, vol. 276, no. 23, pp. 1907–1915, 1996. View at Google Scholar · View at Scopus
  6. I. P. Connoley, D. J. Heal, and M. J. Stock, “A study in rats of the effects of sibutramine on food intake and thermogenesis,” British Journal of Pharmacology, vol. 114, supplement, p. 388, 1995. View at Google Scholar
  7. J. C. G. Halford, D. J. Heal, and J. E. Blundell, “Effects in the rat of sibutramine on food intake and the behavioural satiety sequence,” British Journal of Pharmacology, vol. 114, supplement, p. 387, 1995. View at Google Scholar
  8. I. P. Connoley, Y.-L. Liu, I. Frost, I. P. Reckless, D. J. Heal, and M. J. Stock, “Thermogenic effects of sibutramine and its metabolites,” British Journal of Pharmacology, vol. 126, no. 6, pp. 1487–1495, 1999. View at Google Scholar · View at Scopus
  9. R. Guerciolini, “Mode of action of orlistat,” International Journal of Obesity, vol. 21, supplement 3, pp. S12–S23, 1997. View at Google Scholar · View at Scopus
  10. J. Zhi, A. T. Melia, C. Funk et al., “Metabolic profiles of minimally absorbed orlistat in obese/overweight volunteers,” Journal of Clinical Pharmacology, vol. 36, no. 11, pp. 1006–1011, 1996. View at Google Scholar · View at Scopus
  11. M. C. Mancini and A. Halpern, “Investigational therapies in the treatment of obesity,” Expert Opinion on Investigational Drugs, vol. 15, no. 8, pp. 897–915, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. A. Kaya, N. Aydin, P. Topsever et al., “Efficacy of sibutramine, orlistat and combination therapy on short-term weight management in obese patients,” Biomedicine and Pharmacotherapy, vol. 58, no. 10, pp. 582–587, 2004. View at Publisher · View at Google Scholar · View at PubMed
  13. N. Aydin, P. Topsever, A. Kaya, M. Karasakal, C. Duman, and A. Daǧar, “Orlistat, sibutramine, or combination therapy: which performs better on waist circumference in relation with body mass index in obese patients?” Tohoku Journal of Experimental Medicine, vol. 202, no. 3, pp. 173–180, 2004. View at Publisher · View at Google Scholar
  14. T. A. Wadden, R. I. Berkowitz, L.G. Womble, D. B. Sarwer, M. E. Arnold, and C. M. Steinberg, “Effects of sibutramine plus orlistat in obese women following 1 year of treatment by sibutramine alone: a placebo-controlled trial,” Obesity Research, vol. 8, no. 6, pp. 431–437, 2000. View at Google Scholar
  15. C. Hanotin, F. Thomas, S. P. Jones, E. Leutenegger, and P. Drouin, “A comparison of sibutramine and dexfenfluramine in the treatment of obesity,” Obesity Research, vol. 6, no. 4, pp. 285–291, 1998. View at Google Scholar
  16. C. Hanotin, F. Thomas, S. P. Jones, E. Leutenegger, and P. Drouin, “Efficacy and tolerability of sibutramine in obese patients: a dose-ranging study,” International Journal of Obesity, vol. 22, no. 1, pp. 32–38, 1998. View at Google Scholar
  17. G. A. Bray, G. L. Blackburn, J. M. Ferguson et al., “Sibutramine produces dose-related weight loss,” Obesity Research, vol. 7, no. 2, pp. 189–198, 1999. View at Google Scholar
  18. M. L. Drent, I. Larsson, T. William-Olsson et al., “Orlistat (RO 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study,” International Journal of Obesity, vol. 19, no. 4, pp. 221–226, 1995. View at Google Scholar
  19. L. F. Van Gaal, J. I. Broom, G. Enzi, and H. Toplak, “Efficacy and tolerability of orlistat in the treatment of obesity: a 6-month dose-ranging study,” European Journal of Clinical Pharmacology, vol. 54, no. 2, pp. 125–132, 1998. View at Publisher · View at Google Scholar
  20. E. Muls, J. Kolanowski, A. Scheen, and L. Van Gaal, “The effects of orlistat on weight and on serum lipids in obese patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled, multicentre study,” International Journal of Obesity, vol. 25, no. 11, pp. 1713–1721, 2001. View at Publisher · View at Google Scholar · View at PubMed