Comparative Evaluation of Whole Body and Hepatic Insulin Resistance Using Indices from Oral Glucose Tolerance Test in Morbidly Obese Subjects with Nonalcoholic Fatty Liver Disease

Figure 1

Box plot analysis of surrogate markers of hepatic and whole body insulin resistance along the spectrum of NAFLD. (a) HOMA-IR and (b) 1/QUICKI calculated from fasting insulin and glucose levels represent hepatic (central) insulin resistance. (c) 1/$\text{IS}{\text{I}}_{\mathrm{0,120}}$ and (d) 1/WBISI calculated from both fasting and 2 hours postglucose challenge insulin and glucose levels represent whole body insulin resistance, which is composite of hepatic and peripheral insulin resistance. Groups were compared by nonparametric test (Kruskal-Wallis $H$ test) and post hoc corrections. $*=P<.01$ and $\#=P<.05$.

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