Review Article

Maintenance of Weight Loss in Adolescents: Current Status and Future Directions

Table 1

Characteristics of Adolescent Clinical Trials.

AuthorSample sizeMethod(s) of data analysisAttrition at end of studyLength of treatmentLength of followup (i.e., months after treatment completion)

Mellin et al. [34]66Not clear; presumably completers only16%3 months12 months
Jiang et al. [35]75Completers only8%24 monthsNone
Coates et al. [36]31Not clear; presumably completers onlyNone reported20 weeks9 months
Brownell et al. [37]42Not clear; presumably completers only14%16 months (sessions were held every 2 months after the initial 16 weekly sessions)None
Wadden et al. [38]47Completers only34%4 months6 months
Coates et al. [39]42ITT, in which return to baseline weight was assumed for participants who did not provide data14%20 weeks6 months
Resnicow et al [40]147(1) ITT (unclear how missing data were handled), and (2) inclusion of only those participants who completed at least 75% of treatment sessions27%6 months6 months
Ebbeling et al. [41]16ITT, in which return to baseline weight was assumed for participants who did not provide data (completers analysis also reported in paper, with same result)13%6 months6 months
Gutin et al. [42]80(1) Completers only and (2) inclusion of only those participants who attended at least 40% of treatment sessions and at least two sessions per week of physical activity29%8 monthsNone
Jelalian et al. [43]76(1) Completers only and (2) ITT, in which return to baseline weight was assumed for participants who did not provide data26%4 months6 months
Williamson et al. [44]57ITT with LOCF (authors also noted that same results were found with completers analyses)30%24 monthsNone
Doyle et al. [45]80(1) Completers only and (2) ITT, in which return to baseline weight was assumed for participants who did not provide data17%4 months4 months
Jones et al. [46]105(1) Completers only and (2) ITT, in which return to baseline weight was assumed for participants who did not provide data17%4 months5 months
Chanoine et al. [47]539Modified ITT: inclusion of all randomized participants who completed at least one postbaseline visit, with LOCF for subsequent missing data35%12 monthsNone
Ozkan et al. [48]42Completers only17%Mean 1 1 . 7 ± 3 . 7 monthsNone

Note: ITT : Intention-to-treat analysis; LOCF= last observation carried forward.