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Journal of Obesity
Volume 2010, Article ID 831901, 6 pages
http://dx.doi.org/10.1155/2010/831901
Clinical Study

Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents

1Post Graduate Program of Nutrition, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, Brazil
2Department of Biosciences, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, Brazil
3Imaging Diagnostic, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, Brazil
4Association Found of Incentive to Physicobiology, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, Brazil
5Department of Psychobiology, Paulista Medicine School, Federal University of São Paulo, UNIFESP-EPM, 04020-060 São Paulo, Brazil

Received 26 August 2009; Revised 2 December 2009; Accepted 15 December 2009

Academic Editor: Alfredo Halpern

Copyright © 2010 Lian Tock et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Machado and H. Cortez-Pinto, “Non-alcoholic fatty liver disease and insulin resistance,” European Journal of Gastroenterology and Hepatology, vol. 17, no. 8, pp. 823–826, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Tock, W. L. Prado, D. A. Caranti et al., “Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy,” European Journal of Gastroenterology and Hepatology, vol. 18, no. 12, pp. 1241–1245, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Bugianesi, E. Gentilcore, R. Manini et al., “A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease,” American Journal of Gastroenterology, vol. 100, no. 5, pp. 1082–1090, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. A. R. Dâmaso, W. L. do Prado, A. de Piano et al., “Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents,” Digestive and Liver Disease, vol. 40, no. 2, pp. 132–139, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. D. van der Poorten, K.-L. Milner, J. Hui et al., “Visceral fat: a key mediator of steatohepatitis in metabolic liver disease,” Hepatology, vol. 48, no. 2, pp. 449–457, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. N. C. Chavez-Tapia, F. Sanchez-Avila, F. Vasquez-Fernandez, A. Torres-Machorro, F. I. Tellez-Avila, and M. Uribe, “Non-alcoholic fatty-liver disease in pediatric populations,” Journal of Pediatric Endocrinology and Metabolism, vol. 20, no. 10, pp. 1059–1073, 2007. View at Google Scholar · View at Scopus
  7. M. Freemark, “Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin,” Acta Paediatrica, vol. 96, no. 9, pp. 1326–1332, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. I. Zuhri-Yafi, P. G. Brosnan, and D. S. Hardin, “Treatment of type 2 diabetes mellitus in children and adolescents,” Journal of Pediatric Endocrinology and Metabolism, vol. 15, supplement 1, pp. 541–546, 2002. View at Google Scholar · View at Scopus
  9. M. Freemark and D. Bursey, “The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes,” Pediatrics, vol. 107, no. 4, pp. E55–E60, 2001. View at Google Scholar · View at Scopus
  10. R. H. Lustig, M. L. Mietus-Snyder, P. Bacchetti, A. A. Lazar, P. A. Velasquez-Mieyer, and M. L. Christensen, “Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children,” Journal of Pediatrics, vol. 148, no. 1, pp. 23–29, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. T. S. Burgert, E. J. Duran, R. Goldberg-Gell et al., “Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance,” Pediatric Diabetes, vol. 9, no. 6, pp. 567–576, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. Centers for Disease Control and Prevention, National Center for Health Statistics. CDC growth charts: United States, May 2000, http://www.cdc.gov/growthcharts/.
  13. J. M. Tanner and R. H. Whitehouse, “Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty,” Archives of Disease in Childhood, vol. 51, no. 3, pp. 170–179, 1976. View at Google Scholar
  14. J. B. Schwimmer, R. Deutsch, J. B. Rauch, C. Behling, R. Newbury, and J. E. Lavine, “Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease,” Journal of Pediatrics, vol. 143, no. 4, pp. 500–505, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. WHO (World Health Organization), “Obesity: preventing and managing the global epidemic,” Report of a WHO Consultation, World Health Organization, Geneva, Switzerland, 2004. View at Google Scholar
  16. F. F. Ribeiro-Filho, A. N. Faria, S. Azjen, M.-T. Zanella, and S. R. G. Ferreira, “Methods of estimation of visceral fat: advantages of ultrasonography,” Obesity Research, vol. 11, no. 12, pp. 1488–1494, 2003. View at Google Scholar · View at Scopus
  17. S. Saadeh, Z. M. Younossi, E. M. Remer et al., “The utility of radiological imaging in nonalcoholic fatty liver disease,” Gastroenterology, vol. 123, no. 3, pp. 745–750, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. NRC, Dietary Reference Intake: Applications in Dietary Assessment, National Academic Press, Washington, DC, USA, 2001.
  19. A. de Piano, W. L. Prado, D. A. Caranti et al., “Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease,” Journal of Pediatric Gastroenterology and Nutrition, vol. 44, no. 4, pp. 446–452, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. “ACSM position stand on the appropriate intervention strategies for weight loss and prevention of weight regain for adults,” Medicine & Science in Sports & Exercise, vol. 33, no. 12, pp. 2145–2156, 2001.
  21. L. M. Alba and K. Lindor, “Review article: non-alcoholic fatty liver disease,” Alimentary Pharmacology and Therapeutics, vol. 17, no. 8, pp. 977–986, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. J.-W. Park, G. Jeong, S. J. Kim, M. K. Kim, and S. M. Park, “Predictors reflecting the pathological severity of non-alcoholic fatty liver disease: comprehensive study of clinical and immunohistochemical findings in younger Asian patients,” Journal of Gastroenterology and Hepatology, vol. 22, no. 4, pp. 491–497, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. V. Nobili, M. Marcellini, R. Devito et al., “NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice,” Hepatology, vol. 44, no. 2, pp. 458–465, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. J.-F. Fu, L. Liang, C.-C. Zou et al., “Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention,” International Journal of Obesity, vol. 31, no. 1, pp. 15–22, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. R. S. Hundal and S. E. Inzucchi, “Metformin: new understandings, new uses,” Drugs, vol. 63, no. 18, pp. 1879–1894, 2003. View at Publisher · View at Google Scholar
  26. T. J. Orchard, M. Temprosa, R. Goldberg et al., “The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the diabetes prevention program randomized trial,” Annals of Internal Medicine, vol. 142, no. 8, pp. 611–619, 2005. View at Google Scholar · View at Scopus
  27. K. M. Utzschneider and S. E. Kahn, “The role of insulin resistance in non-alcoholic fatty liver disease,” Journal of Clinical Endocrinology & Metabolism, vol. 91, pp. 4753–4761, 2006. View at Google Scholar
  28. A. N. Rodrigues, A. J. Perez, J. G. P. Pires et al., “Cardiovascular risk factors, their associations and presence of metabolic syndrome in adolescents,” Jornal de Pediatria, vol. 85, no. 1, pp. 55–60, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Uygun, A. Kadayifci, A. T. Isik et al., “Metformin in the treatment of patients with non-alcoholic steatohepatitis,” Alimentary Pharmacology and Therapeutics, vol. 19, no. 5, pp. 537–544, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. K. J. Nadeau, L. B. Ehlers, P. S. Zeitler, and K. Love-Osborne, “Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents,” Pediatric Diabetes, vol. 10, no. 1, pp. 5–13, 2009. View at Publisher · View at Google Scholar