Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK𝛽 Action in a Fiber-Type Specific Manner

Figure 2

The effect of vehicle (open bars) or metformin (filled bars) on I$\kappa$B$\alpha$ levels in soleus, RG, and WG (a) and the correlation between AMPK and I$\kappa$B$\alpha$ (b) in WG from obese and lean male Zucker rats. Equal loading of proteins was ensured by probing for actin. $P<.05$ for vehicle versus metformin treatment within same phenotype $({}^{*})$ and lean versus obese within a given treatment (#). AMPK activation and I$\kappa$B$\alpha$ levels were significantly correlated in WG ($r=0.755,\mathrm{\hspace{0.17em}\hspace{0.17em}}P<.005$).

(a)

(b)