Research Article

Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner

Figure 2

The effect of vehicle (open bars) or metformin (filled bars) on IκBα levels in soleus, RG, and WG (a) and the correlation between AMPK and IκBα (b) in WG from obese and lean male Zucker rats. Equal loading of proteins was ensured by probing for actin. P<.05 for vehicle versus metformin treatment within same phenotype (*) and lean versus obese within a given treatment (#). AMPK activation and IκBα levels were significantly correlated in WG (r=0.755,  P<.005).