Research Article

Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner

Figure 3

The effect of vehicle (open bars) or metformin (filled bars) on IRS1-pSer307 in soleus, RG, and WG (a) and the correlation between IκBα and IRS1-pSer307 (b) in WG from obese and lean Zucker male rats. P<.05 for vehicle versus metformin treatment within same phenotype (*) and lean versus obese within a given treatment (#). IκBα and IRS1-pSer307 levels were significantly related in WG (r=-0.789,P<.01).