Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK𝛽 Action in a Fiber-Type Specific Manner

Figure 3

The effect of vehicle (open bars) or metformin (filled bars) on IRS1-pSer³⁰⁷ in soleus, RG, and WG (a) and the correlation between IκBα and IRS1-pSer³⁰⁷ (b) in WG from obese and lean Zucker male rats. $P<.05$ for vehicle versus metformin treatment within same phenotype $({}^{*})$ and lean versus obese within a given treatment (#). I$\kappa$B$\alpha$ and IRS1-pSe${\text{r}}^{307}$ levels were significantly related in WG ($r=-0.789,$$P<.01$).

(a)

(b)