SNP ID Position Parameter association Population Adiponectin level
valueReference rs860291 −12823 No association with T2DM, BMI, or insulin sensitivity Pima Indians [24 ] rs16861194 −11426 SNP associated with increased risk for gaining weight in diabetics Chinese (T2DM) [35 ] SNP associated with fasting plasma glucose in T2DM patients and in those with impaired glucose tolerance Swedish Caucasians (T2DM/ impaired glucose tolerance/ nondiabetic) [36 ] G allele moderately associated with T2DM French Caucasians [37 ] rs17300539 −1391 A allele associated with higher adn levels, higher BMI, and obesity Children of European origin 13.39 6.00E -08 [33 ] A allele carriers have lower weight, waist and hip circumferences and BMI [32 ] GA carriers had increased risk for becoming hyperglycaemic/diabetic French Caucasians [34 ] A allele associated with higher adn levels French Caucasians .0001 [23 ] A allele associated with higher adn levels Hispanic Americans and African Americans 18.89 .0001 [27 ] A allele associated with higher adn levels Caucasians [38 ] A allele associated with higher adn levels Caucasian women 36.93 .0006 [39 ] A allele associated with higher adn levels in obese children French Caucasians (obese/lean) .005 [31 ] A allele associated with higher adn Caucasian and African American adolescents 29.41 .002 [40 ] A allele associated with higher adn levels Caucasians 19.05 .0005 [41 ] A associated with lower adn levels, lower insulin sensitivity, and higher risk of T2DM in obese subjects French Caucasians (lean/obese) 32.01 .0003 [42 ] rs266729 −11377 C allele associated with higher fasting plasma glucose levels in diabetics Chinese (T2DM) [35 ] C allele associated with severe obesity French Caucasians (obese/lean) [31 ] G allele associated with lower adn levels, higher risk of hypertension Chinese (hypertensive) .0037 [43 ] SNP associated with increase in plasma oxidative stress markers T2DM patients [44 ] G allele associated with lower adn levels, lower insulin sensitivity, and higher risk of T2DM in obese subjects French Caucasians (lean/obese) 20.66 .008 [42 ] G allele associated with coronary stenoses and lower adn levels European men with CVD 26.92 .003 [45 ] SNP associated with increased risk for colorectal cancer Czech patients [46 ] No association with adn levels Caucasian Italians [32 ] No association with colorectal cancer risk UK [47 ] GG and CG associated with lower CRC risk American CRC patients [48 ] G associated with lower adn levels French Caucasians .0003 [23 ] CC and CG genotypes had higher BMI than GG Swedish Caucasians (T2DM/ impaired glucose tolerance/ nondiabetic) [36 ] −11365 SNP associated with lower plasma adn levels 18.36 .007 [49 ] No association with T2DM, BMI, or insulin sensitivity Pima Indians [24 ] −10677 SNP associated with lower adn levels Chinese (hypertensive) .0027 [43 ] rs182052 −10068 A allele associated with lower adn levels Hypertensive Chinese .0001 [43 ] A allele associated with waist circumference American Caucasian young adults [50 ] G allele associated with higher adn Caucasian and African American adolescents 17.58 0.03 [40 ] −10066 G allele associated with higher adn Caucasian women 8.67 .01 [39 ] rs16861209 −7734 C > A A allele associated with higher adn Caucasian women 22.68 .004 [39 ] rs822395 −4041 A > C No association with adn levels Caucasian Italians [32 ] −4034 CC associated with CVD risk [49 ] −3971 G > A A allele associated with worse glucose tolerance and insulin sensitivity, but not adn levels Caucasian Canadians (nondiabetic) [51 ] rs2241766 +45 T > G GG and TG genotypes were at higher risk for T2DM Obese Iranians [52 ] Both TG and GG genotypes were associated with gestational T2DM, whereas among healthy participants, the TT genotype had higher adn levels than other groups Pregnant (<18 weeks) Malaysian women 19.92 .05 [53 ] G allele associated with lower fasting insulin levels and lower HOMA-IR score Nondiabetic Greek women [54 ] G allele associated with higher TG, HOMA, fasting blood glucose, BMI and ALT, and lower adn levels; T allele associated with lower body weight Chinese (NAFLD/metabolic syndrome) 28.68 .008 [55 ] GG associated with T2DM Japanese [56 ] G allele associated with T2DM (lower insulin sensitivity), lower adn, higher blood pressure, higher LDL and total cholesterol levels Chinese (T2DM) 15.47 .01 [57 ] A allele associated with worse glucose tolerance and insulin sensitivity, but not adn levels Caucasian Canadians (nondiabetic) [51 ] G allele associated with BMI and waist circumference Hispanic Americans [58 ] GG carriers had higher risk of becoming hyperglycaemic/diabetic, associated with increase in BMI and WHR over 3 years French Caucasian [34 ] No difference in risk for T2DM or IR Korean (diabetic/ nondiabetic) [59 ] T allele and TG genotype associated with lower serum adn, no association with IR Caucasians 25.17 .0008 [60 ] GT genotype associated with impaired glucose tolerance Spanish [61 ] G allele conferred higher risk of developing T2DM than TT genotype, particularly when combined with SNP +276 T allele European/Canadian subjects with impaired glucose tolerance [62 ] T allele associated with lower BMI and HOMA-IR Japanese (nondiabetic) [63 ] In obese subjects, serum cholesterol and waist circumference were lower in TG genotype than in TT genotype Swedish women (obese/lean) [64 ] No association with adn levels Caucasian Italians [32 ] No association with risk for coronary artery disease Caucasian Italians (T2DM) [65 ] No association with T2DM, BMI, or insulin sensitivity Pima Indians [24 ] G allele associated with coronary artery disease in T2DM patients European Caucasians [66 ] G associated with higher adn levels French Caucasians .01 [23 ] rs1501299 +276 G > T T allele associated with obesity African American men [67 ] GG associated with T2DM, higher insulin resistance, and lower adn levels in subjects with higher BMI Japanese 10.40 .01 [56 ] T allele associated with higher adn levels Caucasian women 4.46 .0031 [39 ] T allele associated with central obesity and hyperglycemia Indigenous Taiwanese [68 ] T allele associated with lower adn levels, diastolic blood pressure Finnish men 33.58 .001 [69 ] T allele associated with higher fasting insulin levels and higher HOMA-IR score, possible association with body fat Greek women (nondiabetic) [54 ] GG genotype associated with lower adn levels, impaired glucose tolerance Spanish .015 [61 ] SNP associated with higher rate of insulin resistance, higher n-6/n-3 LCPUFA ratio in plasma phospholipids Normolipidaemic obese children [70 ] T allele associated with severe obesity, but not adn French Caucasians (obese/lean) [31 ] TT genotype associated with lower CVD risk in diabetic patients, those without CVD had higher adn levels American men (T2DM) 27.03 .0029 [71 ] T allele is an important determinant of CAD and lower adn levels in patients with early onset CAD (50 years of age or less) Italian CAD patients [72 ] T allele associated with higher adn Caucasian and African American adolescents 4.95, 5.81 .05,.03 [40 ] G allele carriers had higher TG, higher small dense LDL, and smaller LDL particle size; GG had lower adn, higher HOMA-IR Korean (nondiabetic) 18.90 .026 [73 ] No association with adn levels or hypertension Japanese men (hypertensive/ normotensive) [74 ] No difference in allele frequencies between diabetic and nondiabetic, no difference in risk of T2DM or insulin resistance Korean (diabetic/ nondiabetic) [59 ] No association with T2DM, BMI, or insulin sensitivity Pima Indians [24 ] TT genotype associated with lower risk of coronary artery disease in T2DM patients Caucasian Italians (T2DM) [65 ] TT genotype associated with higher adn levels Caucasian Italians .032 [32 ] G allele, GT genotype associated with lower serum adn, no association with insulin resistance Caucasians 13.70 .00005 [60 ] T allele associated with lower BMI and HOMA-IR Japanese (nondiabetic) [63 ] T associated with higher adn levels French Caucasians .01 [23 ] rs1063538 +3228 C > T T allele associated with higher adn levels Caucasian women 24.97 .036 [39 ] rs1063538 +3286 No association with T2DM, BMI, or insulin sensitivity Pima Indians [24 ] +10211 T > G G allele associated with higher diabetes risk, higher BMI, and lower adn levels Asian Indians .007 [75 ] rs12495941 G > T T allele associated with lower adn levels Chinese (hypertensive) .0001 [43 ] rs3774261 A > G G allele associated with IR African Americans [76 ] rs1656943 (rs822387) T > C C allele associated with higher adn levels Hispanic Americans and African Americans 12.62 .003 [27 ]
