Absolute weight loss: weight loss from baseline; NS: not significant; NR: not recorded; WC: waist circumference; P: placebo; B: bupropion; N: naltrexone; Z: zonisamide; R: rimonabant; T: tesofensine; NA: not available; ∗pooled non-diabetic patients; #mean ± standard deviation; ∧estimated absolute weight based on mean baseline weight of 100 kg.