Journal of Obesity / 2011 / Article / Tab 6 / Review Article
Pharmacotherapies for Obesity: Past, Current, and Future Therapies Table 6 Recent randomised controlled trials of weight loss therapies with 2-years followup.
Drug No subjects Outcomes Serious adverse events Reference Absolute weight loss (kg) (95% CI) ≥5% weight loss ≥10% weight loss Change in WC (cm) Lorcaserin P-684
50.3% 7.7%
NS [120 ] L-564
67.9% 22.6%
Taranabant P-244 1.4 (0.3, 2.5) 30.3% 13.4 −2.7 (1.5, 3.8) NS [23 ] TB 2 mg-264 6.4 (5.3, 7.4),
59.6,
33,
1 −6.3 (5.2, 7.4)
TB 4 mg-260 7.6 (6.5, 8.7),
64.8,
37.9,
−7.0 (5.9, 8.1),
Absolute weight loss = weight loss from baseline; WC: waist circumference, NR: not recorded, TB: taranabant, NS: not significant; P: placebo; L: lorcaserin.