Research Article

Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine

Table 4

(a) Differences between ephedrine- and placebo-related changes in overnight macronutrient oxidation and energy expenditure, between treated (days 1 and 14) and untreated (day 0), and between chronic and acute treatments (days 14 and 1)

IntervalProteinCarbohydrateFatEnergy
daysdifference (kJ) difference (kJ) difference (kJ) difference (kJ)

1-0 46.7.75 41.4.86150.8.1462.7.05
14–0 95.9.3210.8.98190.3.05105.2.001
14–1 46.2.7352.2.7839.5.8642.5.23

(b) Differences between ephedrine and placebo treatment effects on changes in macronutrient oxidation and energy expenditure over 23 h, from 22:00 to 21:00, between treated (days 1 and 14) and untreated (day 0), and between chronic and acute treatments (days 14 and 1)

IntervalProteinCarbohydrateFatEnergy
daysdifference (kJ) difference (kJ) difference (kJ) difference (kJ)

1-0131.9.5214.5.9936.7.99183.2.48
14–0285.8.06 61.0.93 94.9.92129.9.69
14–1153.8.41 75.6.90 161.6.85 53.3.94