Sequence Analysis of the UCP1 Gene in a Severe Obese Population from Southern Italy

Table 2

UCP1 sequence variations and their frequencies in obese and control subjects.

Polymorphisms		Obese patients			Control subjects
		𝑛=100			𝑛=100
Position	rs#	wt	HE	HO	wt	HE	HO
g.−637T>C^1		99	1	0	100	0	0
g.−451C>T	rs36207410	82	16	2	86	14	0
g.−412A>C	rs3811787	57	36	7	49	43	8
g.−372A>C	rs1800660	97	3	0	97	3	0
g.−206C>A^1		99	1	0	100	0	0
g.−56C>T	rs3749539	91	9	0	90	10	0
g.−17C>G^1		94	6	0	94	6	0
g.12A>C	rs10011540	91	9	0	90	10	0
g.21G>A	rs1800661	86	13	1	79	21	0
g.940G>A (p.A64T)	rs45539933	92	8	0	91	9	0
g.IVS2+138C>T	rs7688743	80	15	5	70	27	3
g.IVS2+174T>A^1		99	1	0	100	0	0
g.IVS2+201T>G	rs2071416	79	21	0	77	22	1
g.IVS4−208T>G^2	rs1494808	45	44	11	69	23	8
g.6537A>T (p.M229L)	rs2270565	89	11	0	87	13	0

¹New variants; ²More frequent polymorphism in obese patients (𝑃=.002) than in controls. wt: wild-type homozygous subjects; HE: heterozygous and HO: homozygous subjects at level of the detected variant.