An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans

Table 1

Subject characteristics and effect of rs17782313 on obesity measures and peripheral insulin sensitivity.

Genotype	TT	TC/CC	𝑃
𝑁 (%)	30 (59%)	21 (41%)	—
Gender (F/M)	14/16	12/9	—
Age (years)	33±2	38±3	.14
Weight (kg)	81.4±3.4	83.9±3.6	.47*
BMI (kg/m²)	27.1±0.9	28.4±1.0	.62*
Body fat (%)	27.1±1.6	30.5±1.9	.57*
Waist circumference (cm)	92±3	95±3	.34*
Fasting plasma glucose (mmol/L)	4.9±0.1	5.1±0.1	.35*
2 Hr glucose (mmol/L)**	6.1±0.3	6.6±0.4	.51*
Insulin sensitivity index (μmol⋅kg/^−1⋅pM^−1)***	0.074±0.009	0.062±0.010	.67*

M ± SE; *adjusted for age and gender; **OGTT; ***Hyperinsulinemic euglycemic clamp.