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Journal of Obesity
Volume 2011, Article ID 307542, 7 pages
http://dx.doi.org/10.1155/2011/307542
Research Article

Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier

1School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
2MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol BS8 2BN, UK
3Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Hyderabad, India
4Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
5Bloomsbury Centre for Genetic Epidemiology and Statistics, London WC1E 6BT, UK
6South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi 110 016, India
7Centre for Chronic Disease Control, New Delhi 110 016, India
8Public Health Foundation of India, New Delhi 110 016, India

Received 2 December 2010; Accepted 4 March 2011

Academic Editor: Yvon Chagnon

Copyright © 2011 A. E. Taylor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table S1: Genotype frequencies in sample of unrelated individuals from the whole study.

Supplementary Table S2: Genotype frequencies in sample of unrelated individuals from Lucknow.

Supplementary Table S3: Genotype frequencies in sample of unrelated individuals from Nagpur.

Supplementary Table S4: Genotype frequencies in sample of unrelated individuals from Hyderabad.

Supplementary Table S5: Genotype frequencies in sample of unrelated individuals from Bangalore.

Supplementary Table S6: Demographic and cardiovascular and metabolic outcomes in the study population stratified by obesity.

Supplementary Table S7: Associations of rs12970134 with age, sex adjusted Z-scores of obesity traits.

Supplementary Table S8: Age, sex adjusted associations of SNPs in FTO and MC4R genes with obesity.

Supplementary Table S9: Interactions between obesity SNPs and sex in associations with obesity traits.

Supplementary Table S10: Interactions between rs12970134 and rural/urban dwelling in associations with obesity phenotypes.

Supplementary Table S11: Interactions of FTO with tertiles of physical activity in associations with BMI and weight.

Supplementary Table S12: MX analyses: Association between obesity SNPs and traits.

Supplementary Table S13: MX analyses: Interactions between rural/urban location and genetic variants in their associations with obesity traits.

  1. Supplementary Tables