Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G>A Promoter Variant (rs659366)

Table 1

Studied high frequency variants of the UCP2 and UCP3 genes.

Gene	Variant	Acc. number	Approximate frequency (ref)
UCP2	Promoter −1957G>A	rs649446	29.0% (A-allele) [59]
UCP2	Promoter −866G>A	rs659366	37.0% (A-allele) [60]
UCP2	Codon 55 Ala/Val	rs660339	39.6% (Val) [61]
UCP2	3′UTR ins>del	—	29.6% (ins-allele) [62]
UCP3	Promoter −55C>T	rs1800849	26.9% (T-allele) [63]
UCP3	Exon 3 Tyr99Tyr	rs1800006	30.0% (T-allele) [59]
UCP3	Exon 5 Tyr210Tyr	rs2075577	16.0% (T-allele) [59]