Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes

Table 3

Echocardiographic parameters in severely obese subjects with type 2 diabetes before and after treatment.

	Normal values	Control group		Treatment group
		Pre	Post	Pre	Post
N		13	13	16	16
Aortic root (mm)	20–37	33 ± 4	35 ± 4*	33 ± 4	33 ± 4^‡
IVS (mm)	6–11	11 ± 1^1	11 ± 1^1	11 ± 2^1	11 ± 2
PW (mm)	6–11	10 ± 2^1	10 ± 1^1	11 ± 1^1	10 ± 1*
LA (mm)	19–40	42 ± 4	41 ± 5	42 ± 4	41 ± 3
RV diastolic (mm)	7–23	26 ± 4	26 ± 4	26 ± 3	26 ± 3
LV diastolic (mm)	35–57	53 ± 8	54 ± 9	50 ± 4	51 ± 3
LV systolic (mm)	20–39	34 ± 9^2	35 ± 10^1	29 ± 4^1	30 ± 4
LV mass (g/m)^4	M < 163	226 ± 74^2	233 ± 61^2	209 ± 53^3	198 ± 46^2*
	W < 121
Ejection fraction (%)	>50	60 ± 11	60 ± 13	64 ± 5	67 ± 4

Mean ± standard deviation; *𝑃<.05: pre versus post; ^‡𝑃<.05: control versus treatment; IVS: Interventricular septum; LA: Left atrium; LV: Left ventricle; PW: Posterior wall; RV: Right ventricle.
¹One missing subject.
²Two missing subjects.
³Three missing subject.
⁴Normal values: <163 g/m for men and <121 g/m for women [24].