Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue
Figure 4
Influence of 8-week oral administration of semicarbazide on benzylamine-induced glucose transport in mouse adipocytes. Visceral adipocytes were incubated with 0.1 mM benzylamine alone (bza) or combined with 0.1 mM vanadate (bza + van) for 2-DG uptake assay. Data are expressed as percentage of response to 100 nM insulin, which maximally stimulated basal uptake by 3.3 ± 0.4-fold in control (black columns) and by 4.8 ± 0.8-fold in semicarbazide-drinking mice (open columns). Mean ± SEM of 8 determinations. Different from control at .
