Relationships of Adrenoceptor Polymorphisms with Obesity

Table 1

Summary of studies showing associations between on β1-adrenoceptor polymorphisms and obesity.

Authors (reference)	Year	Population	Subjects	Findings
Dionne et al. [60]	2002	Caucasian	931 women	Arg allele of Argt389Gly was associated with obesity (greater body weight and BMI due to greater fat mass).
Tafel et al. [61]	2004	German	Children and adolescents	The distributions of Ser49Gly and Arg389Gly were not different between lean and obese adolescents.
Linné et al. [62]	2005	Scandinavian	761 women	The combination of Gly49-Gly389 (Ser49Gly + Arg389Gly) was associated with long term of 15 years weight gain and the incidence of adult-onset overweight in women, but no effect of Arg389Gly alone on obesity.
Gjesing et al. [63]	2007	Danish-Caucasians	7,677	Arg389Gly polymorphism was not related with obesity, but minor influence on BP.
Nonen et al. [64]	2008	Japanese	188 type 2 diabetic patients	Ser49Gly, but not Arg389Gly, was associated with obesity.

BP: blood pressure.