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Journal of Obesity
Volume 2012, Article ID 102942, 8 pages
Clinical Study

Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study

1Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
2Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
3Alzheimer’s Disease Center at Boston university, Boston, MA 02215, USA
4Department of Health Sciences, Northeastern University, Boston, MA 02115, USA

Received 12 September 2012; Revised 6 November 2012; Accepted 27 November 2012

Academic Editor: David Allison

Copyright © 2012 Xian-Yong Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Brain-derived neurotrophic factor (BDNF) has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265) in the BDNF gene with dietary intake for obesity traits in the Boston Puerto Rican Health Study. BDNF rs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men ( ) with the GG genotype had higher BMI ( ), waist circumference ( ), hip ( ), and weight ( ) than GA or AA carriers ( ). They had twice the risk of being overweight ( ) relative to GA or AA carriers (OR = 2.08, CI = 1.02–4.23, and ). Interactions between rs6265 and polyunsaturated fatty acids (PUFA) intake were associated with BMI, hip, and weight, and n-3 : n-6 PUFA ratio with waist circumference in men. In contrast, women ( ) with the GG genotype had significantly lower BMI ( ), hip ( ), and weight ( ) than GA or AA carriers ( ). Women with the GG genotype were 50% less likely to be overweight compared to GA or AA carriers (OR = 0.05, CI = 0.27–0.91, and ). In summary, BDNF rs6265 is differentially associated with obesity risk by sex and interacts with PUFA intake influencing obesity traits in Boston Puerto Rican men.