Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis

Figure 4

(a) [³H]-oleic acid uptake curves for cardiomyocytes from control, HFD, db/db, and ob/ob mice. Data points are mean ± SE. (b) 𝑉_max for saturable cardiomyocyte LCFA uptake is increased in all obesity groups compared with the control group. Bars represent mean ± 1 SE. *indicates 𝑃<0.05 compared to controls. (c) Relationship between serum insulin concentration and [³H]-oleic acid uptake 𝑉_max, indicating a significant nonlinear correlation which may reflect, in part, insulin resistance.

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