Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis

Table 1

Heart weights and lipid content. Heart weights and cardiac triglyceride and cholesterol content were measured. Data reported as mean ± SE. Results of ANOVA, followed by post hoc t-tests.

Group	Heart weight (g)	Heart triglycerides (mg)	Heart cholesterol (mg)
Control (𝑛=30)	0.125 ± 0.002	0.68 ± 0.16	0.68 ± 0.07
HFD (𝑛=19)	0.145 ± 0.006**	1.40 ± 0.22^*‡	0.54 ± 0.16
db/db (𝑛=7)	0.143 ± 0.002*	2.73 ± 0.32**	3.71 ± 1.06**
ob/ob (𝑛=22)	0.157 ± 0.006**	2.87 ± 0.35^**§§	5.89 ± 1.99^**§

* 𝑃<0.05, ** 𝑃<0.01 compared with the control group. ^‡𝑃<0.01 (HFD versus db/db); ^§𝑃<0.05, ^§§𝑃<0.01 (HFD versus ob/ob).