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Journal of Obesity
Volume 2012, Article ID 208953, 7 pages
Research Article

Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding

1Division of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, Italy
2I.N.Di.M., National Institute for Mediterranean Diet and Nutrigenomic, 87032 Amantea, Italy
3Dietology and nutrition Unit, San Camillo-Forlanini Hospital, 00151 Rome, Italy
4Department of Internal Medicine, University of Tor Vergata, 00133 Rome, Italy

Received 30 November 2011; Accepted 12 March 2012

Academic Editor: Natan Zundel

Copyright © 2012 Laura Di Renzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Recent data demonstrated that the 174 G>C IL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery. Objective. We investigated the impact of 174 G>C IL-6 polymorphism on weight loss, body composition, and fluid distribution changes in obese subjects after LAGB. Design and Outcome Measures. Twenty obese subjects were selected and studied at baseline and 3 months after LAGB. Genetic assessment of 174 G>C IL-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed. Results. At baseline, C(+) carriers had a lower extracellular water (ECW) and higher intra-CW, phase angle (PA), reactance Xc, and Xc/height. LAGB surgery determined significant reductions in weight and BMI. After LAGB, in C(−) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, and Xc/H were highlighted. In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), and R/height were obtained. Significant higher reductions in BMI and Xc/H were observed in C(+) with respect to C(−) carriers. Conclusions. Genotyping of genetic variants, for example, the 174 G>C polymorphism of IL-6, gives the opportunity to predict therapeutic response, in terms of body composition outcomes after LAGB.