Table 1: Baseline characteristics of the study population.

Characteristic BMI, 18.5–29.9 ( 𝑛 = 5 1 1 ) BMI, ≥30.0 ( 𝑛 = 3 0 0 ) 𝑃 -value

Age, years 5 3 . 8 ± 7 . 5 5 2 . 5 ± 6 . 7 0.01
Non-Hispanic white, % 73.4 66.3 0.03
Cardiorespiratory fitness, METs* 1 1 . 2 ± 3 . 5 9 . 2 ± 3 . 0 <0.001
Unfit, %* 25.2 47.0 <0.001
Fit, %* 74.8 53.0
Resting heart rate (bpm) 7 6 . 1 ± 1 4 . 1 7 9 . 2 ± 1 4 . 7 0.003
Resting blood pressure (mmHg)
 Systolic 1 3 0 . 3 ± 1 8 . 2 1 3 4 . 9 ± 1 8 . 7 <0.001
 Diastolic 8 3 . 9 ± 1 0 . 6 8 6 . 4 ± 1 2 . 1 0.002
Hypertension, % 32.3 56.3 <0.001
Hypercholesterolemia, % 33.6 44.9 0.002
Cardiovascular medication use, %
 Betablockers9.820.0<0.001
 Calcium antagonists10.019.0<0.001
 Antihypertensives16.623.30.02
 Antiarrhythmics1.61.30.79
 ACE inhibitors4.712.7<0.001
 Anticoagulants9.413.70.06
 Statins4.34.00.83
 Diuretics1.02.70.06
All-cause deaths, % 11.9 11.3 0.80
Followup, years 8 . 9 ± 5 . 4 8 . 3 ± 5 . 0 0.12

Data shown are mean ± SD unless otherwise specified. 𝑃 values were calculated from the 𝑡 -test for continuous variables and chi-square for categorical variables. BMI, body mass index; METs, metabolic equivalents.
*1 MET = 3.5 mL/kg/min oxygen uptake, calculated from final treadmill speed and grade during maximal exercise test; lower third (<9 METs) and upper two-thirds (≥9 METs) of cohort were classified as unfit and fit, respectively.