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Journal of Obesity
Volume 2012, Article ID 985902, 16 pages
Research Article

Combined Effects of Aerobic Exercise and Diet on Lipids and Lipoproteins in Overweight and Obese Adults: A Meta-Analysis

1Department of Community Medicine, School of Medicine, West Virginia University, P.O. Box 9190, Morgantown, WV 26506-9190, USA
2Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111-1524, USA
3Prevention Research Center, Stanford University, Palo Alto, CA 94305-2004, USA

Received 18 August 2011; Accepted 1 December 2011

Academic Editor: Eliot Brinton

Copyright © 2012 George A. Kelley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study used the aggregate data meta-analytic approach to determine the combined effects of aerobic exercise and diet on lipids and lipoproteins in overweight and obese adults. Twelve studies representing 859 men and women (443 intervention, 416 control) were included. Using random-effects models, statistically significant, intervention minus control reductions were found for TC (−12.8 mg/dL, 95% CI, −19.9 to −5.7), TC : HDL-C (−0.5 mg/dL, 95% CI, −0.8 to −0.1), LDL-C (−6.8 mg/dL, 95% CI, −11.8 to −1.8), and TG (−13.1 mg/dL, 95% CI, −21.2 to −5.0) but not HDL-C (−0.4 mg/dL, 95% CI, −2.3 to 1.6). Results remained robust when adjusted for publication bias, deleting each study from the model once, and collapsing results for multiple groups from the same study into one effect size. These findings suggest that concurrent aerobic exercise and diet improve TC, LDL-C, TC : HDL-C, and TG, but not HDL-C, in overweight and obese adults.