Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects
Table 1
Clinical characteristics, lipids and inflammatory markers in subjects with type 2 diabetes, and normal glucose tolerance before (pre) and 1 wk, 3 mo, and 1 yr after Roux-en-Y gastric bypass.
Pre
1 wk
3 mo
1 yr
valueII
(% of total)
T2D
10 (50)
9 (47)
10 (53)
10 (50)
NGT
10 (50)
10 (53)
9 (47)
10 (50)
Systolic BP, mmHg*
T2D
136 (15)
131 (13)
134 (10)
138 (12)
0.517
0.295
NGT
135 (6)
136 (12)
136 (12)
130 (14)
0.411
value‡
0.876
0.432
0.788
0.214
Diastolic BP, mmHg*
T2D
83 (7)
79 (8)
81 (7)
83 (9)
0.512
0.117
NGT
81 (11)
75 (9)
78 (6)
73 (9)
0.010
value‡
0.598
0.313
0.383
0.036
Weight, Kg*
T2D
125.9 (14.4)
124.5 (13.9)
109.0 (15.6)
96.9 (20.6)
<0.0001
0.578
NGT
130.3 (10.4)
127.2 (9.6)
108.8 (7.6)
98.0 (12.1)
<0.0001
value‡
0.441
0.628
0.972
0.886
BMI, Kg/m2*
T2D
42.5 (5.7)
41.9 (6.0)
36.8 (6.1)
32.8 (8.2)
<0.0001
0.738
NGT
42.5 (4.6)
41.4 (4.2)
35.2 (2.9)
32.1 (4.4)
<0.0001
value‡
0.977
0.830
0.483
0.797
WHR*
T2D
1.0 (0.1)
1.1 (0.1)
1.1 (0.1)
1.0 (0.1)
0.030
0.589
NGT
1.1 (0.1)
1.1 (0.1)
1.0 (0.1)
1.0 (0.1)
0.017
value‡
0.917
0.650
0.647
0.832
TG, mmol/L*
T2D
1.51 (0.36)
1.58 (0.22)
1.38 (0.45)
1.10 (0.39)
0.017
0.385
NGT
1.35 (0.46)
1.61 (0.53)
1.17 (0.44)
0.98 (0.41)
0.005
value‡
0.400
0.867
0.311
0.512
FFA, mmol/L*
T2D
0.80 (0.25)
0.92 (0.22)
0.74 (0.20)
0.54 (0.12)
<0.0001
0.859
NGT
0.73 (0.30)
0.78 (0.19)
0.70 (0.26)
0.50 (0.28)
0.087
value‡
0.587
0.162
0.710
0.690
YKL-40, µg/L†
T2D
51 (37; 88)
47 (35; 71)
62 (49; 110)
59 (35; 94)
0.120
0.362
NGT
43 (22; 99)
61 (31; 76)
44 (31; 88)
51 (27; 97)
0.930
value‡
0.388
0.947
0.156
0.449
MCP-1, pg/mL†
T2D
25.2 (11.3; 35.5)
20.4 (9.0; 24.4)
15.9 (8.6; 19.9)
9.7 (6.4; 11.9)
<0.0001
0.213
NGT
14.9 (12.4; 42.1)
17.8 (13.7; 34.4)
13.1 (9.2; 22.9)
11.1 (6.6; 16.1)
<0.0001
value‡
0.920
0.533
0.887
0.333
Data are presented as *mean (SD), †median (IQR), or number (%) where not specified. ‡ value for comparison of T2D and NGT; Independent Samples -test. -value for overall comparison between days within a group (T2D or NGT); repeated measures. value for overall comparison of changes between the groups (T2D and NGT); repeated measures. BMI: body mass index; DBP: diastolic blood pressure; FFA: free fatty acids; MCP-1: monocyte chemoattractant protein-1; NGT: normal glucose tolerance; SBP: systolic blood pressure; T2D: type 2 diabetes; TG: triglyceride; WHR: waist-hip ratio.
