Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects
Table 2
I-AUC values for postprandial concentrations of YKL-40, MCP-1, FFA, and triglycerides in subjects with type 2 diabetes and normal glucose tolerance before (pre) and 1 wk, 3 mo, and 1 yr after Roux-en-Y gastric bypass.
Pre
1 wk
value‡
3 mo
value‡
1 yr
value‡
(% of total)
T2D
10 (50)
9 (47)
10 (53)
10 (50)
NGT
10 (50)
10 (53)
9 (47)
10 (50)
I-AUC YKL-40, μg/L/t*
T2D
−31.38 (−56.0; −13.72)
5.25 (−10.56; 12.25)
0.008
−27.56 (−64.90; −18.00)
0.866
−0.75 (−12.56;13.94)
0.007
NGT
−18.44 (−31.69; −6.41)
−0.19 (−16.53; 6.60)
0.386
−15.38 (−20.31; 5.56)
0.260
−2.75 (−13.35; −17.78)
0.114
value†
0.174
0.414
0.022
0.821
I-AUC MCP1, pg/mL/t*
T2D
−14.62 (−36.38; −0.19)
−8.81 (−16.58; −2.33)
0.139
−8.80 (−27.02; 0.67)
0.721
−7.65 (−17.14; −1.39)
0.114
NGT
−7.78 (−21.28; −1.42)
−7.79 (−14.02; −1.63)
0.445
−1.37 (−11.52; 21.01)
0.441
−3.32 (−5.69; 2.65)
0.093
value†
0.705
0.935
0.121
0.226
I-AUC FFA, mmol/L/t*
T2D
−1.14 (−1.84; −0.61)
−0.82 (−1.66; −0.64)
0.859
−1.16 (−1.52; −0.94)
0.878
−1.16 (−1.38; −0.64)
0.508
NGT
−0.69 (−1.71; 0.49)
−0.68 (−1.19; −0.37)
0.333
−1.36 (−1.75; −0.78)
0.441
−0.77 (−1.24; 0.03)
0.203
value†
0.450
0.191
0.806
0.151
I-AUC TG, mmol/L/t*
T2D
0.91 (0.26; 1.58)
0.11 (−0.18; 0.45)
0.028
0.18 (−0.06; 0.49)
0.013
0.46 (0.03; 0.70)
0.059
NGT
0.92 (0.55; 1.52)
0.05 (−0.23; 0.22)
0.007
0.31 (0.10; 0.59)
0.011
0.30 (0.06; 0.60)
0.074
value†
0.762
0.306
0.414
0.677
Median (IQR). † value: comparison between groups (T2D/NGT). Mann-Whitney U-test. ‡ value: compared to baseline (pre). Wilcoxon matched-pairs signed-rank test. I-AUC: incremental area under the curve; MCP-1: monocyte chemoattractant protein-1; FFA: free fatty acids; TG: triglycerides; T2D: type 2 diabetes; NGT: normal glucose tolerance.
