Table of Contents Author Guidelines Submit a Manuscript
Journal of Obesity
Volume 2013 (2013), Article ID 492170, 9 pages
Research Article

Methylation and Expression of Immune and Inflammatory Genes in the Offspring of Bariatric Bypass Surgery Patients

1Department of Food Science and Nutrition, Institute of Nutrition and Functional Foods (INAF), Laval University, Québec, QC, Canada G1V 0A6
2Endocrinology and Nephrology, CHU de Québec Research Center, Québec, QC, Canada G1V 4G2
3Québec Heart and Lung Institute, Québec, QC, Canada G1V 4G5
4Department of Medicine, Laval University, Québec, QC, Canada G1V 0A6
5Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
6Department of Surgery, Laval University, Québec, QC, Canada G1V 0A6

Received 28 March 2013; Revised 17 May 2013; Accepted 22 May 2013

Academic Editor: Matthias Bluher

Copyright © 2013 Frédéric Guénard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Maternal obesity, excess weight gain and overnutrition during pregnancy increase risks of obesity, type 2 diabetes mellitus, and cardiovascular disease in the offspring. Maternal biliopancreatic diversion is an effective treatment for severe obesity and is beneficial for offspring born after maternal surgery (AMS). These offspring exhibit lower severe obesity prevalence and improved cardiometabolic risk factors including inflammatory marker compared to siblings born before maternal surgery (BMS). Objective. To assess relationships between maternal bariatric surgery and the methylation/expression of genes involved in the immune and inflammatory pathways. Methods. A differential gene methylation analysis was conducted in a sibling cohort of 25 BMS and 25 AMS offspring from 20 mothers. Following differential gene expression analysis (23 BMS and 23 AMS), pathway analysis was conducted. Correlations between gene methylation/expression and circulating inflammatory markers were computed. Results. Five immune and inflammatory pathways with significant overrepresentation of both differential gene methylation and expression were identified. In the IL-8 pathway, gene methylation correlated with both gene expression and plasma C-reactive protein levels. Conclusion. These results suggest that improvements in cardiometabolic risk markers in AMS compared to BMS offspring may be mediated through differential methylation of genes involved in immune and inflammatory pathways.