Association of Obesity with Proteasomal Gene Polymorphisms in Children
Table 4
Genotype frequencies in obese children with (OB) and without (NOB) a family history of obesity.
Gene
SNP
Genotyping results
Genotype
Subjects ()
Frequency (%)
Significance values
Subjects ()
Frequency (%)
Significance values
OB
Control
OB
Control
CI 95%
NOB
Control
NOB
Control
CI 95%
PSMA6
c.-110C>A
CC
51
166
86.4
86.9
0.93
0.41–2.26
29
166
90. 6
86.9
0.56
0.41–5.14
CA
8
25
13.6
13.1
3
25
9.4
13.1
AA
0
0
0
0
0
0
0
0
c.-8C>G
CC
49
158
83.0
82.7
0.86
0.45–2.16
26
158
81.2
82.7
0.03
0.43–4.04
CG
10
32
17.0
16.8
4
32
12.5
16.8
GG
0
1
0
0.5
2
1
6.3
0.5
PSMA3
c. 543+138G>A
GG
19
102
32.2
53.4
0.002*
0.17–0.60
16
102
50.0
53.4
0.77
0.36–1.77
GA
38
66
64.4
34.6
13
66
40.6
34.6
AA
2
23
3.4
12.0
3
23
9.4
12.0
SNP: single nucleotide polymorphism. P value based on method. CI 95% indicates confidence interval. OB: subjects with family history of obesity. NOB: subjects without family history of obesity. Significance based on P < 0.05 and CI95 < 1.0.
